The favorite has minus the points, meaning that they must win by more than that number for the bet to hit. There are so many betting markets to target in football, including point spreads, moneylines, totals, parlays, teasers, props, and futures.īefore you decide who to be on in today’s or this week’s NFL games, let’s sum up how to actually place wagers on American football.Įach game is assigned a point spread, which is the projected winning margin. The NFL is by far the most popular league for sports betting in the United States.